MN1

Across TCGA cell cohorts, MN1 mutation is significantly associated with the RNA expression of many other genes, with 1,537 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MN1-associated genes across cancer lineages are E2F2, TMEM239, and RXFP2. Each is linked with MN1 in more than 2 cancer types. Because this analysis shows association rather than direction, both MN1-to-partner and partner-to-MN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, E2F2 grouped by MN1-low versus MN1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MN1→partner) and Y-score (partner→MN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	E2F2 →	+1.006	+3.584	<.001	<.001	3	3
BONE	TMEM239 →	+0.045	+3.688	.002	.007	3	2
LUNG_NSCLC_LUSC	RXFP2 →	+0.023	+4.643	<.001	.008	3	2
LUNG_NSCLC_LUSC	OR13C9 →	+0.090	+4.643	<.001	.008	3	2
LUNG_NSCLC_LUSC	OR52D1 →	+0.073	+4.643	<.001	.008	3	2
BLOOD_Leukemia	NAPG →	+0.529	+3.251	.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,537 associations by consensus.

E2F2 by MN1 expression — LARGE_INTESTINE

Explore this box plot interactively →