MMS22L

Across TCGA patient cohorts, MMS22L mutation is significantly associated with the RNA expression of many other genes, with 2,294 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MMS22L-associated genes across cancer lineages are RNA5SP394, UBE2V1P14, and GFOD1. Each is linked with MMS22L in more than 2 cancer types. Because this analysis shows association rather than direction, both MMS22L-to-partner and partner-to-MMS22L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP394 grouped by MMS22L-low versus MMS22L-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMS22L→partner) and Y-score (partner→MMS22L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	RNA5SP394 →	+0.509	+5.268	<.001	.006	3	3
LUAD	UBE2V1P14 →	+0.029	+4.011	.006	.007	3	3
UCEC	GFOD1 →	-0.506	-2.237	<.001	.001	3	3
COAD	RPSAP35 →	+0.044	+4.983	<.001	.001	3	3
BLCA	MIR3617 →	+0.232	+3.948	.001	.002	3	3
HNSC	MRPS17P9 →	+0.092	+4.355	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,294 associations by consensus.

RNA5SP394 by MMS22L expression — LIHC

Explore this box plot interactively →