MMS22L

Across TCGA patient cohorts, MMS22L mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MMS22L-associated genes across cancer lineages are ERK2, FASN, and Notch1. Each is linked with MMS22L in more than 1 cancer types. Because this analysis shows association rather than direction, both MMS22L-to-partner and partner-to-MMS22L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by MMS22L-low versus MMS22L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMS22L→partner) and Y-score (partner→MMS22L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.161	+1.241	.004	.015	3	2
UCEC	FASN →	+0.344	+1.241	.003	.015	3	2
COAD	Notch1 →	+0.215	+3.008	.025	.019	3	2
UCEC	p27_pT198 →	+0.075	+1.241	.017	.015	3	2
UCEC	RAD51 →	+0.096	+1.807	.019	.025	3	2
UCEC	S6_pS240_S244 →	+0.277	+1.241	.020	.015	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

ERK2 by MMS22L expression — UCEC

Explore this box plot interactively →