MMS22L

Across TCGA cell cohorts, MMS22L mutation is significantly associated with the RNA expression of many other genes, with 267 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MMS22L-associated genes across cancer lineages are BAG2, OR10G9, and LINC02881. Each is linked with MMS22L in more than 1 cancer types. Because this analysis shows association rather than direction, both MMS22L-to-partner and partner-to-MMS22L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BAG2 grouped by MMS22L-low versus MMS22L-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMS22L→partner) and Y-score (partner→MMS22L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BAG2 →	+0.981	+3.364	.003	.002	3	2
PANCREAS	OR10G9 →	+0.030	+5.614	<.001	.002	3	1
PANCREAS	LINC02881 →	+0.022	+5.000	<.001	.006	3	1
LUNG_NSCLC_LUSC	ADGRE3 →	+0.028	+3.584	<.001	.003	3	1
LUNG_NSCLC_LUSC	VN1R3 →	+0.020	+3.584	<.001	.003	3	1
SOFT_TISSUE	LIM2 →	+1.471	+4.930	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 267 associations by consensus.

BAG2 by MMS22L expression — LARGE_INTESTINE

Explore this box plot interactively →