MMRN1

Across TCGA patient cohorts, MMRN1 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MMRN1-associated genes across cancer lineages are Caspase-7-cleavedD198, ATM, and ASNS. Each is linked with MMRN1 in more than 3 cancer types. Because this analysis shows association rather than direction, both MMRN1-to-partner and partner-to-MMRN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by MMRN1-low versus MMRN1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMRN1→partner) and Y-score (partner→MMRN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+0.925	+2.178	.012	.035	3	4
UCEC	ATM →	-0.488	-1.836	<.001	.001	3	4
LUAD	ASNS →	+0.422	+2.459	.013	.017	3	3
LUSC	Shc_pY317 →	-0.168	-2.539	.016	.011	3	3
UCEC	Notch1 →	+0.146	+1.775	<.001	.007	3	3
LUAD	EGFR_pY1068 →	-0.375	-3.169	.033	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

Caspase-7-cleavedD198 by MMRN1 expression — COAD

Explore this box plot interactively →