MMP7

Across TCGA pan-cancer cohorts, MMP7 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated MMP7 data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher MMP7 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated MMP7 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

LUAD, GBM, and CCRCC are the cancer types where MMP7 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	All	0.486	0.932	.003	12	view →
GBM	DFS	Tertile	All	0.251	0.589	.006	11	view →
CCRCC	OS	Median	IV	0.167	0.784	.038	6	view →
UCEC	DFS	Median	All	1.000	0.936	.022	6	view →
PDAC	OS	Median	IV	0.491	0.836	.024	3	view →
HNSC	OS	Median	IV	0.635	0.850	.015	2	view →
LSCC	OS	Tertile	II,III,IV	0.679	0.905	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

MMP7–LUAD (OS)

Open the LUAD breakdown →