MMP7

Across TCGA patient cohorts, MMP7 mutation is significantly associated with the RNA expression of many other genes, with 149 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible MMP7-associated genes across cancer lineages are RNA5SP423, RN7SL440P, and RNA5SP413. Each is linked with MMP7 in more than 2 cancer types. Because this analysis shows association rather than direction, both MMP7-to-partner and partner-to-MMP7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP423 grouped by MMP7-low versus MMP7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMP7→partner) and Y-score (partner→MMP7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP423 →	+1.106	+3.039	<.001	.002	3	3
LIHC	RN7SL440P →	+0.257	+5.108	<.001	.008	3	2
LUSC	RNA5SP413 →	+0.998	+6.081	<.001	.002	3	2
LUSC	RNA5SP206 →	+0.639	+5.151	<.001	.007	3	2
LIHC	ARL4AP1 →	+0.090	+5.355	<.001	.005	3	2
SKCM	RN7SL214P →	+0.086	+4.199	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 149 associations by consensus.

RNA5SP423 by MMP7 expression — UCEC

Explore this box plot interactively →