MMP3

Across TCGA pan-cancer cohorts, MMP3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MMP3 data layer compared with 25 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher MMP3 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated MMP3 expression acts as an unfavorable survival marker, although some lineages such as LSCC and HNSC show a favorable association.

PDAC, LSCC, and LUAD are the cancer types where MMP3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	All	0.267	0.491	.001	40	view →
LSCC	DFS	Tertile	III,IV	0.979	0.514	.015	6	view →
LUAD	DFS	Median	All	0.467	0.828	.040	3	view →
UCEC	DFS	Quartile	All	0.745	1.000	.037	2	view →
HNSC	DFS	Median	III,IV	0.860	0.361	.022	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

MMP3–PDAC (OS)

Open the PDAC breakdown →