MMP3

Across TCGA patient cohorts, MMP3 mutation is significantly associated with the RNA expression of many other genes, with 2,362 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MMP3-associated genes across cancer lineages are MIR3929, SLC36A4, and SGTB. Each is linked with MMP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MMP3-to-partner and partner-to-MMP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3929 grouped by MMP3-low versus MMP3-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMP3→partner) and Y-score (partner→MMP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	MIR3929 →	+0.444	+5.008	.001	.004	3	2
UCEC	SLC36A4 →	+0.663	+2.353	<.001	.003	3	2
SKCM	SGTB →	+0.617	+2.260	.009	.005	3	2
UCEC	MT-CO2 →	-0.528	-2.145	<.001	.003	3	2
UCEC	IGHD2-2 →	+0.917	+1.650	.003	.002	3	2
UCEC	FABP5P10 →	+0.106	+1.520	.008	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,362 associations by consensus.

MIR3929 by MMP3 expression — LIHC

Explore this box plot interactively →