MMP3

Across TCGA patient cohorts, MMP3 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MMP3-associated genes across cancer lineages are Shc_pY317, ASNS, and Caspase-8. Each is linked with MMP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MMP3-to-partner and partner-to-MMP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by MMP3-low versus MMP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMP3→partner) and Y-score (partner→MMP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Shc_pY317 →	-0.130	-1.678	.025	.023	3	2
UCEC	ASNS →	+0.469	+2.000	<.001	.030	3	2
UCEC	Caspase-8 →	-0.235	-3.558	.014	.002	3	2
SKCM	p21 →	-0.525	-1.982	.006	.031	3	2
SKCM	p27_pT198 →	+0.143	+3.016	.013	.018	3	2
UCEC	Ku80 →	+0.227	+1.691	.012	.014	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Shc_pY317 by MMP3 expression — UCEC

Explore this box plot interactively →