MMP3

Across TCGA cell cohorts, MMP3 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,010 significant associations in total. BONE shows the largest number of these associations.

The most reproducible MMP3-associated GO terms across cancer lineages are Regulation of cell-matrix adhesion, Regulation of focal adhesion assembly, and Regulation of cell-substrate junction assembly. Each is linked with MMP3 in more than 7 cancer types. Because this analysis shows association rather than direction, both MMP3-to-partner and partner-to-MMP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cell-matrix adhesion grouped by MMP3-low versus MMP3-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MMP3→partner) and Y-score (partner→MMP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of cell-matrix adhesion →	+0.120	+1.352	<.001	.002	3	8
BONE	Regulation of focal adhesion assembly →	+0.159	+1.803	<.001	.001	3	8
BONE	Regulation of cell-substrate junction assembly →	+0.159	+1.803	<.001	.001	3	8
BONE	Positive regulation of cell-substrate junction organization →	+0.144	+1.785	.001	.002	3	7
BONE	Regulation of cell-substrate junction organization →	+0.142	+1.803	<.001	.001	3	7
BONE	Negative regulation of Rho protein signal transduction →	+0.141	+1.344	<.001	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,010 associations by consensus.

Regulation of cell-matrix adhesion by MMP3 expression — BONE

Explore this box plot interactively →