MMP3

Across TCGA cell cohorts, MMP3 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. URINARY_TRACT shows the largest number of these associations.

The most reproducible MMP3-associated genes across cancer lineages are OTOR, IL9, and PTH. Each is linked with MMP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MMP3-to-partner and partner-to-MMP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OTOR grouped by MMP3-low versus MMP3-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMP3→partner) and Y-score (partner→MMP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	OTOR →	+0.022	+4.087	<.001	.009	3	1
URINARY_TRACT	IL9 →	+0.097	+4.087	<.001	.009	3	1
URINARY_TRACT	PTH →	+0.055	+4.087	<.001	.009	3	1
URINARY_TRACT	CLLU1-AS1 →	+0.085	+4.087	<.001	.009	3	1
URINARY_TRACT	OR4A47 →	+0.020	+4.087	<.001	.009	3	1
URINARY_TRACT	PRSS58 →	+0.102	+4.087	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

OTOR by MMP3 expression — URINARY_TRACT

Explore this box plot interactively →