MMP28

Across TCGA patient cohorts, MMP28 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MMP28-associated genes across cancer lineages are 14-3-3_zeta, CD31, and 14-3-3_beta. Each is linked with MMP28 in more than 1 cancer types. Because this analysis shows association rather than direction, both MMP28-to-partner and partner-to-MMP28 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_zeta grouped by MMP28-low versus MMP28-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMP28→partner) and Y-score (partner→MMP28) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	14-3-3_zeta →	+0.269	+3.169	.017	.019	3	2
UCEC	CD31 →	-0.175	-2.000	.008	.032	3	2
UCEC	14-3-3_beta →	-0.094	-2.973	.037	.035	3	1
UCEC	A-Raf_pS299 →	-0.169	-3.169	.001	.019	3	1
UCEC	FASN →	+0.532	+3.000	.002	.036	3	1
UCEC	FoxM1 →	+0.322	+2.000	.005	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

14-3-3_zeta by MMP28 expression — SKCM

Explore this box plot interactively →