MMP27

Across TCGA pan-cancer cohorts, MMP27 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MMP27 data layer compared with 22 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher MMP27 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated MMP27 expression acts as an unfavorable survival marker.

OV, COAD, and LIHC are the cancer types where MMP27 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	OS	Median	II,III,IV	0.308	0.691	.033	18	view →
COAD	OS	Median	III,IV	0.159	0.692	.021	12	view →
LIHC	OS	Median	All	0.144	0.688	.013	9	view →
SKCM	OS	Median	II,III,IV	0.297	0.735	.005	9	view →
LUAD	OS	Median	II,III,IV	0.307	0.748	.046	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

MMP27–OV (OS)

Open the OV breakdown →