MMP27

Across TCGA pan-cancer cohorts, MMP27 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MMP27 data layer compared with 22 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher MMP27 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated MMP27 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

CCRCC, LUAD, and PDAC are the cancer types where MMP27 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	All	1.000	0.586	.001	24	view →
LUAD	DFS	Quartile	II,III,IV	0.659	0.223	.008	6	view →
PDAC	OS	Tertile	II,III,IV	0.705	0.308	.016	6	view →
HNSC	OS	Quartile	IV	1.000	0.784	.032	2	view →
LSCC	OS	Tertile	All	1.000	0.725	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

MMP27–CCRCC (DFS)

Open the CCRCC breakdown →