MMP27

Across TCGA patient cohorts, MMP27 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible MMP27-associated genes across cancer lineages are HER2, NF2, and RAD51. Each is linked with MMP27 in more than 1 cancer types. Because this analysis shows association rather than direction, both MMP27-to-partner and partner-to-MMP27 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HER2 grouped by MMP27-low versus MMP27-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMP27→partner) and Y-score (partner→MMP27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	HER2 →	+0.336	+2.321	.004	.032	3	1
SKCM	NF2 →	+0.246	+1.700	.025	.043	3	1
SKCM	RAD51 →	-0.235	-3.287	.017	.009	3	1
SKCM	Raptor →	+0.220	+2.321	.003	.033	3	1
UCEC	EGFR →	-0.280	-3.000	.002	.037	1	2
UCEC	ARID1A →	-0.222	-2.992	.035	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

HER2 by MMP27 expression — SKCM

Explore this box plot interactively →