MMP27

Across TCGA cell cohorts, MMP27 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible MMP27-associated genes across cancer lineages are FOLR2, FGF3, and SMIM28. Each is linked with MMP27 in more than 1 cancer types. Because this analysis shows association rather than direction, both MMP27-to-partner and partner-to-MMP27 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOLR2 grouped by MMP27-low versus MMP27-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMP27→partner) and Y-score (partner→MMP27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FOLR2 →	+0.081	+3.716	<.001	.008	3	1
CNS	FGF3 →	+0.053	+4.981	<.001	.008	3	1
CNS	SMIM28 →	+0.046	+5.321	<.001	.005	3	1
LUNG_NSCLC_LUAD	CSN1S1 →	+0.031	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	LACRT →	+0.193	+6.266	<.001	<.001	3	1
LUNG_NSCLC_LUAD	RNASE9 →	+0.025	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

FOLR2 by MMP27 expression — LARGE_INTESTINE

Explore this box plot interactively →