MMP25

Across TCGA pan-cancer cohorts, MMP25 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated MMP25 data layer compared with 25 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher MMP25 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated MMP25 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

PDAC, HNSC, and LUAD are the cancer types where MMP25 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	All	0.379	0.903	.009	36	view →
HNSC	DFS	Quartile	All	0.738	0.431	.012	21	view →
LUAD	OS	Median	III,IV	0.643	1.000	.006	15	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

MMP25–PDAC (DFS)

Open the PDAC breakdown →