MMP25

Across TCGA patient cohorts, MMP25 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MMP25-associated genes across cancer lineages are Caspase-7-cleavedD198, PRDX1, and Shc_pY317. Each is linked with MMP25 in more than 1 cancer types. Because this analysis shows association rather than direction, both MMP25-to-partner and partner-to-MMP25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by MMP25-low versus MMP25-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMP25→partner) and Y-score (partner→MMP25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.968	+2.135	<.001	.010	3	2
UCEC	PRDX1 →	+0.222	+2.584	.008	.010	3	1
UCEC	Shc_pY317 →	-0.173	-3.459	.005	.005	3	1
UCEC	Src_pY416 →	-0.197	-1.794	.048	.027	3	1
UCEC	STAT3_pY705 →	-0.401	-2.574	<.001	.010	3	1
UCEC	VHL →	-1.037	-2.584	<.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Caspase-7-cleavedD198 by MMP25 expression — UCEC

Explore this box plot interactively →