MMP25

Across TCGA cell cohorts, MMP25 mutation is significantly associated with the RNA expression of many other genes, with 167 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MMP25-associated genes across cancer lineages are OR9G1, TMEM213, and OR1J2. Each is linked with MMP25 in more than 1 cancer types. Because this analysis shows association rather than direction, both MMP25-to-partner and partner-to-MMP25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR9G1 grouped by MMP25-low versus MMP25-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMP25→partner) and Y-score (partner→MMP25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR9G1 →	+0.127	+2.967	<.001	.003	3	2
BLOOD_Leukemia	TMEM213 →	+0.080	+2.906	<.001	.004	3	2
CNS	OR1J2 →	+0.024	+3.302	<.001	.003	3	2
OVARY	SLC5A7 →	+0.018	+4.113	<.001	.001	3	2
OVARY	CT47A6 →	+0.015	+3.807	<.001	.009	3	2
BLOOD_Leukemia	ELOVL4 →	+2.030	+3.392	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 167 associations by consensus.

OR9G1 by MMP25 expression — BLOOD_Leukemia

Explore this box plot interactively →