MMP25-AS1

Across TCGA pan-cancer cohorts, MMP25-AS1 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated MMP25-AS1 data layer.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher MMP25-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated MMP25-AS1 expression acts as an unfavorable survival marker, although some lineages such as BRCA and SKCM show a favorable association.

BRCA, KIRC, and SKCM are the cancer types where MMP25-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	DFS	Tertile	III,IV	0.883	0.721	.002	83	view →
KIRC	DFS	Median	All	0.536	0.698	<.001	61	view →
SKCM	OS	Median	All	0.393	0.240	.001	56	view →
KIRP	OS	Quartile	II,III,IV	0.109	0.816	<.001	55	view →
BLCA	OS	Tertile	III,IV	0.739	0.549	.007	36	view →
HNSC	DFS	Quartile	III,IV	0.685	0.503	.003	33	view →
ACC	OS	Quartile	All	0.710	0.980	.001	30	view →
THYM	OS	Median	II,III,IV	0.955	0.721	.007	28	view →
UVM	OS	Median	II,III,IV	0.713	0.500	.018	25	view →
LAML	DFS	Quartile	All	0.732	0.499	.021	24	view →
LGG	DFS	Tertile	All	0.850	0.677	.002	23	view →
THCA	OS	Median	IV	0.570	0.924	.012	22	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

MMP25-AS1–BRCA (DFS)

Open the BRCA breakdown →