MMP24OS

Across TCGA pan-cancer cohorts, MMP24OS RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated MMP24OS data layer compared with 6 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher MMP24OS RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MMP24OS expression acts as an unfavorable survival marker, although some lineages such as MESO and KIRP show a favorable association.

SKCM, MESO, and KIRP are the cancer types where MMP24OS RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.736	0.823	<.001	71	view →
MESO	OS	Tertile	All	0.587	0.302	.001	33	view →
KIRP	OS	Median	II,III,IV	0.908	0.648	.007	23	view →
GBM	DFS	Tertile	All	0.168	0.275	.011	18	view →
BRCA	DFS	Tertile	IV	0.763	0.259	.008	17	view →
READ	DFS	Tertile	III,IV	0.833	0.334	<.001	16	view →
STAD	OS	Quartile	III,IV	0.220	0.646	.009	14	view →
PAAD	DFS	Quartile	All	0.435	0.133	.004	13	view →
LUAD	OS	Tertile	All	0.420	0.223	.034	12	view →
LGG	OS	Median	All	0.850	0.916	.006	12	view →
BLCA	DFS	Tertile	IV	0.138	0.323	.013	11	view →
OV	DFS	Quartile	All	0.134	0.229	.025	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

MMP24OS–SKCM (OS)

Open the SKCM breakdown →