MMP24

Across TCGA patient cohorts, MMP24 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MMP24-associated genes across cancer lineages are 14-3-3_beta, JNK_pT183_Y185, and Notch1. Each is linked with MMP24 in more than 1 cancer types. Because this analysis shows association rather than direction, both MMP24-to-partner and partner-to-MMP24 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by MMP24-low versus MMP24-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMP24→partner) and Y-score (partner→MMP24) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.088	-2.558	.017	.010	3	2
UCEC	JNK_pT183_Y185 →	-0.196	-2.807	.001	.003	3	2
UCEC	Notch1 →	+0.184	+2.335	<.001	.002	3	2
UCEC	PCNA →	+0.198	+2.247	.012	.001	3	2
UCEC	53BP1 →	+0.288	+1.700	.021	.042	3	2
UCEC	EGFR_pY1068 →	-0.221	-2.700	.016	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

14-3-3_beta by MMP24 expression — UCEC

Explore this box plot interactively →