MMP2

Across TCGA pan-cancer cohorts, MMP2 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated MMP2 data layer compared with 21 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher MMP2 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated MMP2 expression acts as an unfavorable survival marker.

LSCC, CCRCC, and PDAC are the cancer types where MMP2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	All	0.935	1.000	.008	17	view →
CCRCC	DFS	Median	II,III,IV	0.128	0.952	.003	12	view →
PDAC	DFS	Median	IV	0.250	0.934	.024	3	view →
LUAD	OS	Median	III,IV	0.395	0.861	.044	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

MMP2–LSCC (OS)

Open the LSCC breakdown →