MMP2

Across TCGA cell cohorts, MMP2 mutation is significantly associated with the RNA expression of many other genes, with 284 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MMP2-associated genes across cancer lineages are PSKH2, OR10H3, and CSN1S1. Each is linked with MMP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MMP2-to-partner and partner-to-MMP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSKH2 grouped by MMP2-low versus MMP2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMP2→partner) and Y-score (partner→MMP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PSKH2 →	+0.038	+5.217	<.001	<.001	3	2
KIDNEY	OR10H3 →	+0.049	+5.000	<.001	.005	3	1
BLOOD_Lymphoma	CSN1S1 →	+0.120	+4.927	<.001	.001	3	1
BLOOD_Lymphoma	STATH →	+0.516	+4.350	<.001	.005	3	1
LUNG_SCLC	OR1K1 →	+0.039	+3.898	<.001	.005	3	1
LUNG_SCLC	CST2 →	+0.051	+3.817	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 284 associations by consensus.

PSKH2 by MMP2 expression — SKIN

Explore this box plot interactively →