MMP2-AS1

Across TCGA pan-cancer cohorts, MMP2-AS1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated MMP2-AS1 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MMP2-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated MMP2-AS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, UVM, and SKCM are the cancer types where MMP2-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	IV	0.414	0.216	.001	140	view →
UVM	DFS	Tertile	All	0.405	0.758	<.001	95	view →
SKCM	OS	Median	All	0.393	0.282	<.001	57	view →
DLBC	DFS	Median	II,III,IV	0.971	0.402	<.001	52	view →
LGG	OS	Median	All	0.718	0.872	<.001	51	view →
LUAD	OS	Median	All	0.415	0.301	.004	39	view →
CESC	DFS	Quartile	All	0.650	0.428	.001	36	view →
ACC	OS	Tertile	II,III,IV	0.704	0.941	.002	27	view →
LIHC	DFS	Tertile	All	0.630	0.468	.010	19	view →
KIRC	DFS	Quartile	All	0.569	0.751	.002	18	view →
GBM	DFS	Tertile	All	0.180	0.291	.010	15	view →
CHOL	DFS	Tertile	All	1.000	0.316	.026	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

MMP2-AS1–HNSC (DFS)

Open the HNSC breakdown →