MMP19

Across TCGA patient cohorts, MMP19 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MMP19-associated genes across cancer lineages are PCNA, c-Myc, and INPP4B. Each is linked with MMP19 in more than 2 cancer types. Because this analysis shows association rather than direction, both MMP19-to-partner and partner-to-MMP19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by MMP19-low versus MMP19-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMP19→partner) and Y-score (partner→MMP19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.205	+2.087	.013	.005	3	3
SKCM	c-Myc →	+0.402	+3.000	.011	.036	3	2
UCEC	INPP4B →	-0.279	-2.000	.024	.030	3	2
UCEC	Caspase-7-cleavedD198 →	+0.511	+2.604	.024	.005	3	2
UCEC	Caspase-8 →	-0.215	-3.432	.025	.005	3	2
UCEC	Di-Ras3 →	-0.158	-2.308	.005	.033	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

PCNA by MMP19 expression — UCEC

Explore this box plot interactively →