MMP19

Across TCGA cell cohorts, MMP19 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MMP19-associated genes across cancer lineages are ST8SIA3, DEFA6, and SULT1C3. Each is linked with MMP19 in more than 1 cancer types. Because this analysis shows association rather than direction, both MMP19-to-partner and partner-to-MMP19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ST8SIA3 grouped by MMP19-low versus MMP19-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMP19→partner) and Y-score (partner→MMP19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ST8SIA3 →	+0.083	+4.273	<.001	.006	3	2
PANCREAS	DEFA6 →	+0.135	+4.786	<.001	.001	3	1
PANCREAS	SULT1C3 →	+0.290	+4.491	<.001	.003	3	1
PANCREAS	MS4A12 →	+0.028	+4.011	<.001	.009	3	1
PANCREAS	SI →	+0.188	+4.237	<.001	.006	3	1
LARGE_INTESTINE	DMRTB1 →	+0.074	+3.347	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

ST8SIA3 by MMP19 expression — SKIN

Explore this box plot interactively →