Across TCGA patient cohorts, MMP17 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MMP17-associated genes across cancer lineages are 14-3-3_beta, eEF2, and EGFR_pY1068. Each is linked with MMP17 in more than 1 cancer types. Because this analysis shows association rather than direction, both MMP17-to-partner and partner-to-MMP17 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMP17→partner) and Y-score (partner→MMP17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.103	-3.295	.006	.009	3	1
UCEC	eEF2 →	+0.420	+2.115	.001	.017	3	1
UCEC	EGFR_pY1068 →	-0.337	-3.321	<.001	<.001	3	1
UCEC	eIF4E →	+0.244	+3.335	.002	.005	3	1
UCEC	A-Raf_pS299 →	-0.131	-2.906	.003	.001	3	1
UCEC	ERK2 →	+0.212	+2.222	.003	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Exploration

MMP17 survival (RNA) · tumor vs normal (RNA) · all MMP17 data types