Across TCGA cell cohorts, MMP17 mutation is significantly associated with the mutation status of many other genes, with 4,054 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MMP17-associated genes across cancer lineages are CACNA1D, SBNO1, and TYRO3. Each is linked with MMP17 in more than 4 cancer types. Because this analysis shows association rather than direction, both MMP17-to-partner and partner-to-MMP17 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMP17→partner) and Y-score (partner→MMP17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CACNA1D →	+1.980	+2.807	.001	.001	1	5
CNS	SBNO1 →	+4.459	+5.277	.005	.005	1	4
SKIN	TYRO3 →	+4.239	+5.053	.007	.007	1	4
BLOOD_Leukemia	SLC4A3 →	+2.591	+3.263	.004	.004	1	4
BLOOD_Leukemia	ADGRB2 →	+2.465	+3.686	.001	.001	1	4
BLOOD_Leukemia	OSMR →	+2.591	+3.263	.004	.004	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,054 associations by consensus.

Exploration

MMP17 survival (RNA) · tumor vs normal (RNA) · all MMP17 data types