MMP15

Across TCGA patient cohorts, MMP15 mutation is significantly associated with the RNA expression of many other genes, with 1,039 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MMP15-associated genes across cancer lineages are DHODH, TTC19, and SLF1. Each is linked with MMP15 in more than 1 cancer types. Because this analysis shows association rather than direction, both MMP15-to-partner and partner-to-MMP15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DHODH grouped by MMP15-low versus MMP15-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMP15→partner) and Y-score (partner→MMP15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DHODH →	+0.398	+3.971	<.001	<.001	3	2
UCEC	TTC19 →	+0.496	+3.040	<.001	<.001	3	2
UCEC	SLF1 →	+0.393	+2.914	.005	.001	3	2
CESC	MRPS10P2 →	+0.173	+5.539	<.001	.004	3	2
BRCA	RNA5SP136 →	+0.217	+4.866	<.001	.003	3	2
BRCA	MOXD2P →	+0.083	+3.968	.008	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,039 associations by consensus.

DHODH by MMP15 expression — UCEC

Explore this box plot interactively →