MMP15

Across TCGA patient cohorts, MMP15 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MMP15-associated genes across cancer lineages are Rictor_pT1135, EGFR_pY1068, and GAPDH. Each is linked with MMP15 in more than 1 cancer types. Because this analysis shows association rather than direction, both MMP15-to-partner and partner-to-MMP15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rictor_pT1135 grouped by MMP15-low versus MMP15-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMP15→partner) and Y-score (partner→MMP15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rictor_pT1135 →	-0.095	-2.459	.021	.018	3	2
UCEC	EGFR_pY1068 →	-0.238	-1.906	.018	.016	3	1
UCEC	GAPDH →	+0.459	+2.321	.033	.033	3	1
UCEC	GATA6 →	-0.128	-2.321	.040	.034	3	1
UCEC	JNK_pT183_Y185 →	-0.151	-1.700	.026	.042	3	1
UCEC	JNK2 →	+0.324	+2.415	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Rictor_pT1135 by MMP15 expression — UCEC

Explore this box plot interactively →