MMP15

Across TCGA cell cohorts, MMP15 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,005 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible MMP15-associated GO terms across cancer lineages are Glycerophospholipid metabolic process, ERBB3 signaling pathway, and ERBB2-ERBB3 signaling pathway. Each is linked with MMP15 in more than 10 cancer types. Because this analysis shows association rather than direction, both MMP15-to-partner and partner-to-MMP15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Glycerophospholipid metabolic process grouped by MMP15-low versus MMP15-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MMP15→partner) and Y-score (partner→MMP15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Glycerophospholipid metabolic process →	+0.042	+1.064	<.001	.002	3	11
LIVER	ERBB3 signaling pathway →	+0.213	+1.929	.002	.003	3	10
LIVER	ERBB2-ERBB3 signaling pathway →	+0.213	+1.929	.002	.003	3	10
URINARY_TRACT	Protein localization to cell junction →	+0.110	+1.701	.004	.003	3	9
KIDNEY	Regulation of oligodendrocyte differentiation →	+0.142	+1.315	<.001	.001	3	9
CNS	Phospholipid biosynthetic process →	+0.039	+1.239	<.001	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,005 associations by consensus.

Glycerophospholipid metabolic process by MMP15 expression — CNS

Explore this box plot interactively →