MMP15

Across TCGA cell cohorts, MMP15 mutation is significantly associated with the RNA expression of many other genes, with 30 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MMP15-associated genes across cancer lineages are HIGD1C, USP17L3, and USP14. Each is linked with MMP15 in more than 1 cancer types. Because this analysis shows association rather than direction, both MMP15-to-partner and partner-to-MMP15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HIGD1C grouped by MMP15-low versus MMP15-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMP15→partner) and Y-score (partner→MMP15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HIGD1C →	+0.108	+5.201	<.001	.006	3	1
BLOOD_Leukemia	USP17L3 →	+0.022	+4.922	<.001	.009	3	1
LARGE_INTESTINE	USP14 →	+0.772	+3.067	.001	.009	3	1
LARGE_INTESTINE	ALDH6A1 →	+1.207	+3.064	<.001	.009	3	1
LARGE_INTESTINE	ULBP3 →	+0.938	+3.064	.003	.009	3	1
LARGE_INTESTINE	PPA2 →	+0.712	+3.064	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

HIGD1C by MMP15 expression — BLOOD_Leukemia

Explore this box plot interactively →