MMP14

Across TCGA pan-cancer cohorts, MMP14 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated MMP14 data layer compared with 26 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher MMP14 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated MMP14 expression acts as an unfavorable survival marker.

CCRCC, PDAC, and LSCC are the cancer types where MMP14 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	II,III,IV	0.273	0.736	<.001	67	view →
PDAC	DFS	Median	All	0.663	0.849	.006	52	view →
LSCC	OS	Median	All	0.736	0.898	.004	23	view →
HNSC	OS	Median	II,III,IV	0.625	0.832	.008	11	view →
LUAD	OS	Quartile	II,III,IV	0.292	0.869	.005	6	view →
GBM	DFS	Tertile	All	0.274	0.502	.004	5	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

MMP14–CCRCC (DFS)

Open the CCRCC breakdown →