MMP13

Across TCGA pan-cancer cohorts, MMP13 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated MMP13 data layer compared with 22 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher MMP13 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated MMP13 expression acts as an unfavorable survival marker.

LUAD, LSCC, and HNSC are the cancer types where MMP13 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	All	0.460	0.821	<.001	25	view →
LSCC	DFS	Median	II,III,IV	0.485	1.000	.013	13	view →
HNSC	OS	Median	II,III,IV	0.645	0.825	.018	5	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

MMP13–LUAD (DFS)

Open the LUAD breakdown →