MMP13

Across TCGA patient cohorts, MMP13 mutation is significantly associated with the RNA expression of many other genes, with 1,428 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MMP13-associated genes across cancer lineages are TRAJ58, MRPS18BP1, and RNA5SP204. Each is linked with MMP13 in more than 2 cancer types. Because this analysis shows association rather than direction, both MMP13-to-partner and partner-to-MMP13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAJ58 grouped by MMP13-low versus MMP13-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMP13→partner) and Y-score (partner→MMP13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	TRAJ58 →	+0.586	+4.973	<.001	.009	3	3
ESCA	MRPS18BP1 →	+0.339	+5.681	<.001	.003	3	3
UCEC	RNA5SP204 →	+0.293	+1.640	<.001	.009	3	3
UCEC	OR5J2 →	+0.059	+1.772	.005	.008	3	3
UCEC	TIPIN →	+0.450	+2.272	<.001	.001	3	3
UCEC	PIMREG →	+0.631	+2.158	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,428 associations by consensus.

TRAJ58 by MMP13 expression — BLCA

Explore this box plot interactively →