MMP13

Across TCGA cell cohorts, MMP13 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,091 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible MMP13-associated GO terms across cancer lineages are Negative regulation of protein catabolic process, Response to topologically incorrect protein, and Viral process. Each is linked with MMP13 in more than 11 cancer types. Because this analysis shows association rather than direction, both MMP13-to-partner and partner-to-MMP13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of protein catabolic process grouped by MMP13-low versus MMP13-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MMP13→partner) and Y-score (partner→MMP13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Negative regulation of protein catabolic process →	+0.088	+0.866	<.001	.008	3	12
PANCREAS	Response to topologically incorrect protein →	+0.097	+1.262	<.001	<.001	3	9
LARGE_INTESTINE	Viral process →	+0.055	+0.263	<.001	.007	3	9
STOMACH	Cellular response to topologically incorrect protein →	+0.089	+0.915	<.001	.007	3	9
SKIN	Chaperone-mediated autophagy →	+0.123	+1.539	<.001	.002	3	9
PANCREAS	Regulation of apoptotic signaling pathway →	+0.046	+0.756	.002	.003	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,091 associations by consensus.

Negative regulation of protein catabolic process by MMP13 expression — STOMACH

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