MMP13

Across TCGA cell cohorts, MMP13 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible MMP13-associated genes across cancer lineages are OR6T1, R3HDML, and OR2B3. Each is linked with MMP13 in more than 1 cancer types. Because this analysis shows association rather than direction, both MMP13-to-partner and partner-to-MMP13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6T1 grouped by MMP13-low versus MMP13-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMP13→partner) and Y-score (partner→MMP13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	OR6T1 →	+0.052	+3.906	<.001	.009	3	1
BLOOD_Lymphoma	R3HDML →	+0.006	+5.209	<.001	.005	3	1
CNS	OR2B3 →	+0.029	+4.321	<.001	.009	3	1
BLOOD_Leukemia	CCKAR →	+0.038	+4.409	<.001	.005	3	1
BLOOD_Leukemia	CYP4A11 →	+0.021	+4.705	.008	.003	3	1
BLOOD_Leukemia	TLE7 →	+0.032	+4.969	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

OR6T1 by MMP13 expression — BLOOD_Myeloma

Explore this box plot interactively →