MMP13

Across TCGA cell cohorts, MMP13 mutation is significantly associated with the mutation status of many other genes, with 750 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MMP13-associated genes across cancer lineages are RIMS1, POU4F2, and PPM1G. Each is linked with MMP13 in more than 2 cancer types. Because this analysis shows association rather than direction, both MMP13-to-partner and partner-to-MMP13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RIMS1 grouped by MMP13-low versus MMP13-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMP13→partner) and Y-score (partner→MMP13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	RIMS1 →	+4.285	+4.285	.003	.003	1	3
CNS	POU4F2 →	+4.614	+4.614	.006	.006	1	3
BLOOD_Lymphoma	PPM1G →	+6.014	+6.014	.001	.001	1	3
LUNG_NSCLC_LUAD	PXK →	+5.584	+4.924	<.001	<.001	1	3
BLOOD_Leukemia	ARHGEF26 →	+4.560	+4.870	<.001	<.001	1	3
LARGE_INTESTINE	ARHGAP21 →	+2.459	+3.321	.005	.005	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 750 associations by consensus.

RIMS1 by MMP13 expression — BLOOD_Myeloma

Explore this box plot interactively →