Across TCGA patient cohorts, MME mutation is significantly associated with the RNA expression of many other genes, with 4,063 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MME-associated genes across cancer lineages are VRK1, WDHD1, and MELK. Each is linked with MME in more than 3 cancer types. Because this analysis shows association rather than direction, both MME-to-partner and partner-to-MME results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MME→partner) and Y-score (partner→MME) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	VRK1 →	+0.633	+3.584	.001	.002	3	4
UCEC	WDHD1 →	+0.629	+3.343	<.001	<.001	3	4
UCEC	MELK →	+0.604	+2.180	.001	.001	3	4
UCEC	UBE2T →	+0.569	+1.578	<.001	.001	3	4
UCEC	GMNN →	+0.501	+2.008	.001	.001	3	4
UCEC	NUSAP1 →	+0.592	+2.098	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,063 associations by consensus.

Exploration

MME survival (RNA) · tumor vs normal (RNA) · all MME data types