Across TCGA patient cohorts, MME mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MME-associated genes across cancer lineages are Lck, Rb_pS807_S811, and Caspase-8. Each is linked with MME in more than 1 cancer types. Because this analysis shows association rather than direction, both MME-to-partner and partner-to-MME results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MME→partner) and Y-score (partner→MME) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Lck →	-0.226	-1.678	.035	.020	3	2
SKCM	Rb_pS807_S811 →	+0.385	+2.700	.005	.005	3	2
UCEC	Caspase-8 →	-0.285	-4.221	<.001	<.001	3	2
UCEC	INPP4B →	-0.256	-1.807	.016	.024	3	2
UCEC	Akt_pS473 →	+0.530	+1.584	.024	.034	3	2
UCEC	Rad50 →	-0.159	-1.986	.047	.029	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

Exploration

MME survival (RNA) · tumor vs normal (RNA) · all MME data types