Across TCGA cell cohorts, MME mutation is significantly associated with the RNA expression of many other genes, with 975 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MME-associated genes across cancer lineages are C18orf63, OR1L6, and OR1L3. Each is linked with MME in more than 1 cancer types. Because this analysis shows association rather than direction, both MME-to-partner and partner-to-MME results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MME→partner) and Y-score (partner→MME) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	C18orf63 →	+0.012	+4.867	<.001	.009	3	2
OVARY	OR1L6 →	+0.012	+4.222	<.001	.006	3	2
BLOOD_Leukemia	OR1L3 →	+0.057	+4.276	.008	.007	3	2
UPPER_AERODIGESTIVE_TRACT	SPEM3 →	+0.026	+3.129	<.001	.007	3	2
LUNG_SCLC	OR52B4 →	+0.014	+4.058	<.001	.007	3	2
LARGE_INTESTINE	ZNF473 →	+0.452	+3.169	.002	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 975 associations by consensus.

Exploration

MME survival (RNA) · tumor vs normal (RNA) · all MME data types