MMADHC

Across TCGA pan-cancer cohorts, MMADHC Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated MMADHC data layer compared with 23 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher MMADHC Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated MMADHC expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

READ, UCEC, and HNSC are the cancer types where MMADHC Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	OS	Median	II,III,IV	0.111	0.919	<.001	33	view →
UCEC	DFS	Median	II,III,IV	1.000	0.442	.029	8	view →
HNSC	OS	Median	All	0.192	0.685	.045	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

MMADHC–READ (OS)

Open the READ breakdown →