MMADHC

Across TCGA pan-cancer cohorts, MMADHC mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated MMADHC data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MMADHC mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated MMADHC expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

HNSC, UCEC, and PDAC are the cancer types where MMADHC mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.995	0.905	.008	22	view →
UCEC	OS	Quartile	II,III,IV	1.000	0.366	.027	12	view →
PDAC	OS	Quartile	II,III,IV	0.363	0.711	.013	11	view →
LUAD	OS	Median	III,IV	0.249	0.701	.037	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

MMADHC–HNSC (DFS)

Open the HNSC breakdown →