MMADHC

Across TCGA patient cohorts, MMADHC mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MMADHC-associated genes across cancer lineages are ATM, Ku80, and Notch1. Each is linked with MMADHC in more than 1 cancer types. Because this analysis shows association rather than direction, both MMADHC-to-partner and partner-to-MMADHC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by MMADHC-low versus MMADHC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMADHC→partner) and Y-score (partner→MMADHC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.718	-2.459	<.001	.019	3	2
UCEC	Ku80 →	+0.261	+2.128	.011	.010	3	1
UCEC	Notch1 →	+0.241	+2.009	<.001	.017	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.552	-2.102	.004	.019	3	1
UCEC	PCNA →	+0.266	+3.321	.004	.009	3	1
UCEC	PDCD4 →	-0.795	-3.459	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

ATM by MMADHC expression — UCEC

Explore this box plot interactively →