MMADHC

Across TCGA cell cohorts, MMADHC RNA expression is significantly associated with the go_rna of many other GO terms, with 2,827 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MMADHC-associated GO terms across cancer lineages are Regulation of DNA damage checkpoint, Chromosome localization, and Regulation of mitotic sister chromatid segregation. Each is linked with MMADHC in more than 11 cancer types. Because this analysis shows association rather than direction, both MMADHC-to-partner and partner-to-MMADHC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of DNA damage checkpoint grouped by MMADHC-low versus MMADHC-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MMADHC→partner) and Y-score (partner→MMADHC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of DNA damage checkpoint →	+0.073	+0.669	.003	.004	3	12
LUNG_NSCLC_LUSC	Chromosome localization →	+0.084	+0.694	.003	<.001	3	11
BREAST	Regulation of mitotic sister chromatid segregation →	+0.094	+0.637	<.001	<.001	3	11
LUNG_NSCLC_LUSC	Metaphase chromosome alignment →	+0.083	+0.694	.004	<.001	3	11
LIVER	Positive regulation of chromosome condensation →	+0.184	+0.543	<.001	.002	3	10
LIVER	Negative regulation of mitotic metaphase/anaphase transition →	+0.130	+0.486	.002	.009	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,827 associations by consensus.

Regulation of DNA damage checkpoint by MMADHC expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →