MMADHC

Across TCGA cell cohorts, MMADHC mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible MMADHC-associated genes across cancer lineages are OR2M5, OR8G5, and MMD2. Each is linked with MMADHC in more than 1 cancer types. Because this analysis shows association rather than direction, both MMADHC-to-partner and partner-to-MMADHC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2M5 grouped by MMADHC-low versus MMADHC-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMADHC→partner) and Y-score (partner→MMADHC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR2M5 →	+0.016	+4.415	<.001	.007	3	1
LARGE_INTESTINE	OR8G5 →	+0.187	+4.467	<.001	.004	3	1
UPPER_AERODIGESTIVE_TRACT	MMD2 →	+0.036	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	COX6A2 →	+0.625	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	UTF1 →	+0.226	+5.357	<.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	USP17L22 →	+0.013	+5.357	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

OR2M5 by MMADHC expression — LARGE_INTESTINE

Explore this box plot interactively →