MMAB

Across TCGA pan-cancer cohorts, MMAB mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated MMAB data layer compared with 21 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher MMAB mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated MMAB expression acts as an unfavorable survival marker, although some lineages such as GBM and LSCC show a favorable association.

CCRCC, GBM, and LSCC are the cancer types where MMAB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	0.668	1.000	.013	7	view →
GBM	OS	Tertile	All	0.937	0.759	.003	7	view →
LSCC	DFS	Quartile	II,III,IV	0.881	0.509	.018	2	view →
PDAC	OS	Quartile	All	0.733	0.931	.026	2	view →
LUAD	OS	Tertile	II,III,IV	1.000	0.513	.040	2	view →
HNSC	DFS	Tertile	II,III,IV	0.874	0.737	.043	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

MMAB–CCRCC (OS)

Open the CCRCC breakdown →