MMAB

Across TCGA patient cohorts, MMAB mutation is significantly associated with the RNA expression of many other genes, with 613 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MMAB-associated genes across cancer lineages are RNA5SP413, RNU6-1169P, and LIN7C. Each is linked with MMAB in more than 1 cancer types. Because this analysis shows association rather than direction, both MMAB-to-partner and partner-to-MMAB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP413 grouped by MMAB-low versus MMAB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMAB→partner) and Y-score (partner→MMAB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP413 →	+1.458	+2.639	<.001	<.001	3	2
SKCM	RNU6-1169P →	+0.408	+5.362	<.001	.005	3	2
UCEC	LIN7C →	+0.585	+3.330	.005	.005	3	1
UCEC	IMMP1L →	+0.460	+2.818	.003	.001	3	1
UCEC	APIP →	+0.495	+2.850	.009	.001	3	1
UCEC	EI24 →	+0.478	+3.906	.008	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 613 associations by consensus.

RNA5SP413 by MMAB expression — UCEC

Explore this box plot interactively →